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Gorlin Syndrome

Gorlin syndrome, also known as nevoid basal cell carcinoma syndrome (NBCCS), is a condition that affects many areas of the body and increases the risk of developing various tumors.

Features of the condition

• Basal cell skin cancer
• Brain cancer
• Jaw cysts

Risk Factors

• Multiple basal cell skin cancers
• Jaw cysts (keratocysts)
• Pits on the palms and soles of feet
• Childhood brain cancer (medulloblastoma)
• Large head size (macrocephaly)
• Skeletal changes, particularly of the skull, spinal column and ribs
• Fibromas of the ovaries or heart
• Eye disease
• Family history of Gorlin syndrome

Genetic Tests

The following genetic tests may be appropriate based on your personal and/or family history:

• PTCH

Schedule an Appointment

To speak with a board-certified genetic counselor about your risks for this disease:

• Schedule genetic counseling appointment online
• Or call 1-800-975-4819
• Send email

Learn More

National Institutes of Health Genetics Home Reference(NIH/GHR)

American Society of Clinical Oncology